Neurodegeneration & Neuroinflammation

Lead by Yuelin Lao, and in collaboration with Paul Worley (Johns Hopkins), Carol Barnes (University of Arizona) and Matthew Huetelman & Ignazio Piras (Translational Genomics Research Institute, TGen), we have a preprint exploring bulk RNA-seq data derived from medial temporal gyrus of nearly 600 donors spanning young and aged controls, high-pathology controls, super-agers, MCI, and AD (biorxiv). We focus our analysis on NPTX2 and potential synaptic resilience mechanisms. This and much more data relevant to Alzheimer's Disease, neurodegeneration more broadly, as well as neuroinflammation can be found at NeMO Analytics.

Here are a few more of our recent publications in neurodegeneration & neuroinflammation:

The figure shown here is from our paper lead by Seth Ament and Peg McCarthy that appeared in Science Translational Medicine as part of the Oct. 13, 2023 BICCN release in the Science family of journals: Early-childhood inflammation blunts the transcriptional maturation of cerebellar neurons. You can explore a collection of our novel snRNA-seq in the cerebellum along with other public datasets in neuroinflammation HERE.

Single-Nucleus RNA-Seq Reveals Dysregulation of Striatal Cell Identity Due to Huntington's Disease Mutations

Genome-Scale Transcriptional Regulatory Network Models of Psychiatric and Neurodegenerative Disorders

Carlo Colantuoni gave a talk on harnessing public multi-omic data for research in neuroinflammation and neurodegeneration at the Johns Hpokins Department of Neurology Grand Rounds in December of 2024 that can be viewed HERE.