Developmental Diversity in a Dish
A new virtual seminar series focusing on stem cell models and functional variation across human iPSC lines. The monthly seminar series is held on the 2nd Tuesday of each month at 1PM (USA eastern time), with two talks in each session, followed by a data-driven follow-up discussion.
Zoom link: https://columbiacuimc.zoom.us/j/99827338471?pwd=aytIdlhNZ0xxSkpjbCszTnRBUVhndz09; Meeting ID: 998 2733 8471; Passcode: 718836
slack page for info and discssion is HERE.
Recordings of past talks are here.
email colantuonicarlo@gmail.com to get added to the email list.
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Upcoming sessions
Session #6: May 14, 2024 @ 1pm Eastern USA time
Dr. Soraya Scuderi (from Dr. Flora Vaccarino's group at Yale University)
"Modelling Regional Specification in Brain Organoids Using a Novel Mesofluidic Device"
and
Dr. Hsiu-Chuan Lin (from Dr. Barbara Treutlein's group at ETH Zürich) "Human neuron subtype programming through combinatorial patterning with scRNA-seq readouts"
Session #7: June 11, 2024 @ 1pm Eastern USA time
Dr. Neal Amin (from Dr. Sergiu Pasca's lab at Stanford) "Generating human neural diversity with a multiplexed morphogen screen in organoids"
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As a way to connect more deeply with the data being presented in the series and discoveries in the field more broadly, we propose the NeMO Analytics platform as a way to explore together. We have already assembled extensive collections of multi-omic data focused on particular cell and developmental contexts - please explore:
human pluripotent stem cell systems
mammalian embryonic development
in vivo neocortical development
in vitro cerebral organoid models
Please reach out to Carlo (colantuonicarlo@gmail.com) if you'd like to add any additional data from your group or other public data you find to be central to our field.
Planning committee: Drs. Ronald McKay, Seungmae Seo, Suel-Kee Kim, and Carlo Colantuoni
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Session #5: April 9, 2024 @ 1PM Eastern US time
Dr. Adithi Sundaresh (From Dr. Helena Kilpinen's group at the University of Helsinki). "Characterization of cortical neurodevelopment in vitro using gene expression and morphology profiles from single cells"
and
Dr. Marcella Birtele (from Dr. Giorgia Quadrato's group at USC). "The autism-associated gene SYNGAP1 regulates human cortical neurogenesis"
Session #4: March 12, 2024 @ 1PM Eastern US time
Dr. Nicolo Caporale (from Dr. Giuseppe Testa's group at Human Technolpole & University of Milan). "Multiplexing cortical brain organoids for the longitudinal dissection of developmental traits at single cell resolution"
and
Dr. Carlo Colantuoni (Depts of Neurology and Neurosciecne, Johns Hopkins University, and Institute for Genome Sciences, University of Maryland)
"Data systems to link in vitro pluripotent stem cell systems to early mammalian development". We looked at individual gene data from in vivo studies https://nemoanalytics.org/p?l=MammalianEmbryo&g=MIXL1 and in vitro systems https://nemoanalytics.org/p?l=Kim2023&g=GBX2. In addition we explored lineage-specific gene signatures from the PCW3 human embryo in these same datasets in vivo https://nemoanalytics.org/p?p=p&l=MammalianEmbryo&c=00be4b21&algo=pca and in vitro https://nemoanalytics.org/p?p=p&l=Kim2024&c=00be4b21&algo=pca.
Session #3: February 13, 2024 @ 1PM Eastern US time
Dr. Seungmae Seo (from Dr. Emily Mace's group at Columbia University)
and
Dr. Nicola Micali (From Dr. Pasko Rakic's group at Yale University)
"The early origins of the cortical disorders modeled with human neural stem cells in vitro"
Session #2: January 9, 2024 @ 1PM Eastern US time
Dr. Taylor Bertucci (from Dr. Sally Temple's group at the Neural Stem Cell Institute)
and
Dr. Suel-kee Kim (from Dr. Nenad Sestan's group at Yale University)
Session #1: December 12, 2023 @ 11AM Eastern US time:
Dr. Alexandre Jourdon (from Dr. Flora Vaccarino's group at Yale University)
and
Dr. Noelia Anton Bolanos (from Dr. Paola Arlotta's group at Harvard University)
"Multi-donor human cortical Chimeroids reveal individual susceptibility to neurotoxic triggers".